Skip to main content

Dr. Burks' Presentation at AAAAI: Related Tweets

So for those of you who are not obsessed with research, this weekend is the annual AAAAI meeting down in San Antonio. A number of immunologists and allergists tweet during the presentations to give those of us who are not lucky enough to attend a glimpse of the presentations.

This morning was Dr. Wesley Burks' highly anticipated talk: Immune Tolerance and Allergy: Can We Produce True Tolerance? Here's what the various tweeters had to say:
Several studies now indicate that food allergy is related to defective T regulatory response” Anne Ellis, M.D ‏@DrAnneEllis
Some studies suggest that when peanut tolerance develops, existing cells do not change, but rather, new populations of cells arise. Peripheral t cell tolerance is key.  Children who have outgrown non IgE-mediated milk allergy demonstrate detectable T regulatory activity. Sakina Bajowala, M.D @allergistmommy
So these are things I've touched on in other columns. Somehow, a child's immune system gets off track when they're first born and develops an immune response that's similar to what the body uses to react to parasites (T2) rather than one that see proteins as harmless (T1).

The $64,000 question is: what, exactly, are these OIT trials (and, by extension, my son's FAHF-2 trial) actually doing? Are they changing the way the body responds? Or are they simply "stretching the balloon" as far as possible, but leaving the maladaptive underlying response intact?

This is important because, if the immune system is really not being changed, then it may be that desensitization and not true tolerance is the best we can hope for.
Allergic individuals form peanut-specific IgE, non-allergic form peanut specific IgG - IgG is a Normal response to a foreign protein. True Peanut allergic patients - their peanut specific IgE continues to rise with ongoing avoidance. Anne Ellis, M.D ‏@DrAnneEllis
Peanut OIT changes antigen specific Tregs and suppresses Th2 response to peanut. Sakina Bajowala, M.D ‏@allergistmommy

So it does appear that these studies are doing something to really change the immune system. That's positive, as there's more hope for true tolerance. It's also important to note that this idea of waiting for IgE levels to fall may not really be the signal for tolerance, as levels generally continue to rise as long as peanut is being avoided. How do the current studies do with regard to inducing desensitization?Assuming it works, how long does it last? Who does it work for?
Burks' studies: OIT for peanut lead to passing a 5000mg challenge while SLIT was only 1000mg. Participants in OIT trials-only 25% passed an oral challenge 4 weeks post treatment discontinuation c/w 75% while still on treatment. Anne Ellis, M.D ‏@DrAnneEllis
41% pts appear to be tolerant after 1-3 years of peanut immunotherapy Matthew Bowdish, M.D ‏@MatthewBowdish
Burks: Peanut OIT - those who developed tolerance had lower baseline PN IgE than those who did not. Dr Melinda Rathkopf ‏@mrathkopf
So there does seem to be a difference in the kids who will respond to the therapy and those who won't. Longer therapy is better. More direct therapy (OIT) works better than smaller doses (SLIT). And, it appears to last for 4 out of 10 kids if it's kept up over time. However, Burks' assessment of all this is:
Critical gaps in OIT/SLIT for food mean its not ready for routine clinical use. David Fischer, MD ‏@IgECPD
A future question to be answered: would starting with younger kids who presumably have more malleable immune systems improve the response? In order to find out:
Impact peanut study. 2000mg maintenance dose for 4 years. Multicenter study. Sakina Bajowala, M.D ‏@allergistmommy
W Burks announces IMPACT study targeting 140 children under 4 with  to peanut.  @WayneShreffler
Burks' next study "Impact" - peanut allergic kids aged 1- 4 to see if OIT will be more likely to induce tolerance if started earlier. Anne Ellis, M.D ‏@DrAnneEllis
So...something to be on the lookout for if you have a child under the age of four and are just starting out on this fun journey.

What a wonderful glimpse into the #AAAAI world!  I am very grateful to these tweeters for sharing these conferences as they occur.

Follow me on Facebook or Twitter  

Popular posts from this blog

Puas Rental dan Sewa Mobil Di Area Cirebon

Puas Rental Mobil Cirebon . Puas Rent car ialah perusahaan transportasi penyedia layanan rental mobil di Cirebon. Puas Rent Car ialah bagian dari perusahaan Puaspark – taman rekreasi keluarga sangat terjangkau di Cirebon Timur. Kami pun melayani lokasi Bekasi sampai Seluruh Cirebon. Armada kami ialah mobil-mobil dalam situasi terawat dan pun mobil-mobil keluaran baru. Dengan opsi mobil yang kami sediakan paling variatif dan harga yang paling kompetitif di Cirebon.
Contact Puas Rental Mobil

Bagi Kami Kepuasan Konsumen nomer Satu..
Untuk Pemesanan klik Rental Mobil Avanza Di Area Cirebon
Karena Disitu Adalah Website Resmi Dari Puas Rental Mobil Cirebon

Puas Rent Car Cirebon menawarkan guna Anda seperti: Avanza. Kami melayani penyewaan mobil guna harian maupun bulanan. Kami meluangkan supir. kita juga dapat menyewa mobil-mobil kami tanpa supir.

Menjadi perusahaan transportasi penyedia jasa penyewaan mobil yang handal. Menjadi parner transportasi terbaik Anda. Terdepan melayani sewa / ren…

inaugural post

The Starker Arts Garden for Education finally has its very own blog. There's so much happening out at the garden that we just couldn't keep all the news from you any longer!

Stay tuned to this blog for updates on SAGE, upcoming event info, sustainable gardening tips, and other good grub fresh from the garden!  Feel free to subscribe to our blog by entering your e-mail address into the "Follow by E-mail" bar to the right.

The Food Allergy Herbal Formula-2 (FAHF-2) Laundry List

So in all the time I've been writing about our experience with FAHF-2, I have never done a comprehensive post with all the links/info I've found over the years. Consider the situation rectified! I'll add to this as I find new sources. If you have good ones, please feel free to add them to the comments as well.

My FAHF-2 Posts
FAHF-2 Trials In Chicago!

We're In

BTDT, Got the FAHF-2 Food Allergy Clinical Trial T-Shirt

Brief FAHF-2 Update

Halfway There...But the Second Half Is All Uphill

FAHF-2: The Holy Grail?

Waiting in the Wings for the Show to Begin

FAHF-2 Clinical Trial Summary

Other People's FAHF-2 Experiences (from around the web)Chinese pharmacy vs. through Dr. Li

For severe eczema/MRSA

New York Times article

For asthma (Vitality magazine)

An asthma patient's personal experience

Description of Dr. Li's treatment plan

What Is FAHF-2?Patent application (contains all ingredients)

Phase 1 Clinical Trial Report (has very specific info about formula ingredients)

Yellow Empero…